Hyaluronan synthase 2 has2
Web16 jan. 2012 · The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report that upregulation of hyaluronan synthase 2 (HAS2) occurs in highly metastatic breast cancer stem–like cells (CSC) defined by CD44 + /CD24 − /ESA + phenotype, where it plays a critical role in the … WebHAS2 is part of cluster 82 Adipose tissue - ECM organization with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and …
Hyaluronan synthase 2 has2
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Web30 mrt. 2024 · Hyaluronan (HA) is a ubiquitous acidic glycosaminoglycan of the vertebrate extracellular matrix that is particularly enriched in connective tissues, the vasculature and … Web24 sep. 2024 · External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and …
Web30 mrt. 2024 · Hyaluronan (HA) is a ubiquitous acidic glycosaminoglycan of the vertebrate extracellular matrix that is particularly enriched in connective tissues, the vasculature and the cartilage 1. HA... WebRecently, hyaluronic acid has been directly involved in the development of liver fibrosis, with hyaluronan synthase 2 (HAS2) having a central role in the production of HA, activation of hepatic stellate cells (HSCs) and in the progression of liver fibrosis. HA promotes HSC activation and liver fibrosis through Notch1 signaling.
Web25 nov. 2016 · This study aimed to determine the role of hyaluronan synthase 2 (HAS2) from CAFs in the progression of oral squamous cell carcinoma (OSCC) invasion. Methods: HAS isoforms 1, 2, and 3 in paired sets of CAFs and normal fibroblasts (NFs) were examined by real-time PCR, and the expression of HAS2 and α-SMA in OSCC tissue … WebELISA Kit for Hyaluronan Synthase 2 (HAS2) ... 将透明质酸合酶2(HAS2)抗体包被于96孔微孔板中，制成固相载体，向微孔中分别加入标准品或标本，其中的透明质酸合酶2(HAS2)与连接于固相载体上的抗体结合，然后加入生物素化的透明质酸合酶2 ...
WebHuman Hyaluronan synthase 2 (HAS2) ELISA kit Citations (1) Protocol Product Details Citations (1) Related Products Customer Reviews and Q&A Target Background Product Details Citations Fermented Dendrobium officinale polysaccharides protect UVA‐induced photoaging of human skin fibroblasts Y Zhang,Food Science & Nutrition,2024 HAS2 …
Web19 jun. 2013 · This high-molecular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity of HA-degrading enzymes and a unique sequence of hyaluronan synthase 2 (HAS2). russian campaign boardgame mapWeb30 mrt. 2024 · The genomic fragments containing HIS were predicted to form hairpin structures in silico similar to miRNA precursors. HIS may function through direct genomic interaction leading to activation of host enhancers, and upregulation of adjacent and distant genes, including cytokine genes and hyaluronan synthase 2 (HAS2). schedule a meeting in email signatureWebab140671 has been referenced in 8 publications. Zhan H et al. Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis. Fertil Steril 114:888-898 (2024). PubMed: 32762950; Würtemberger J et al. Growth inhibition associated with disruption of the actin … schedule a meeting in a private teams channelThere are three mammalian hyaluronan synthases described to date - HAS1, HAS2, and HAS3. Each of these isoforms resides at a different chromosome location and has been cloned. Two of the main differences between the isoforms are the chain length of the hyaluronan molecules that they produce and the ease with which they can be released from the cell surface. When mammalian cells are stimulated by changes in their immediate environment (cytokines, extracellular matrix pr… russian camel wool sweaterWeb17 dec. 2024 · Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) ... russian cake decorating tips flowersWebHyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1) PMID: 22016393; HAS2-HYAL2/CD44 … russian camouflage ukraineWeb13 sep. 2024 · HAS2-OE incrementally increased high-molecular-mass HA >100-fold within the cell-associated and growth medium pools. More importantly, our results indicated … russian camera company editing