SpletPolyglutamine expansion is now recognized to be a major cause of inherited human neurodegenera- tive disease.The polyglutamine expansion diseases identified so far are slowly progressive disorders in which distinct yet overlapping brain regions are selectively vulnerable to degeneration. Splet23. apr. 2015 · Background Although Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized primarily by motor symptoms, PD patients, at all stages of the disease, can experience cognitive dysfunction. However, the relationships between cognitive and motor symptoms and specific demographic characteristics are …
Allele-specific RNA interference for neurological disease
Splet15. dec. 2005 · Miller VM, Gouvion CM, Davidson BL, Paulson HL . Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. … Splet01. jan. 2008 · Huntington’s disease (HD) is a progressive, genetically dominant, neuropsychiatric disorder, which affects voluntary and involuntary motor control, psychiatric symptoms, and cognitive functioning. Since no cure exists for HD at this time, interventions have largely focused on improving motor functioning ( Huntington Study Group, 2003 , … define electronic funds transfer act
Parkinson disease - WHO
SpletWilson's disease is a genetic disorder in which excess copper builds up in the body. Symptoms are typically related to the brain and liver. Liver-related symptoms include vomiting, weakness, fluid build up in the abdomen, … SpletDr. Michelle Paulson is an infectious disease specialist in Pittsburgh, Pennsylvania and is affiliated with multiple hospitals in the area, including Allegheny General Hospital and West Penn... SpletWe emphasize properties of the disease protein, ATXN3, and new discoveries regarding three potential pathogenic mechanisms: 1) altered protein homeostasis; 2) DNA damage … feeling good billy eckstine